Hydrogenated castor oil can be used as a lubricant for tablets. Although its lubricating effect is not as good as magnesium stearate, hydrogenated castor oil is a good choice for a small number of tablets that produce sticking during the compression process, such as clopidogrel bisulfate tablets, which require the use of hydrogenated castor oil as a lubricant.
In fact, most highly polar drugs (hydrophilic drugs) and drugs that are prone to causing flower spots during the tablet pressing process can use hydrogenated castor oil as a lubricant, which can not only provide lubrication, but also prevent sticking and flushing, and have a hydrophobic effect, making it less prone to flower spots.
Hydrogenated castor oil is generally used as a lubricant by external addition, with a dosage of 0.2% -2%
Used as a base for ointments or suppositories
Various plant oils such as castor oil, sesame oil, peanut oil, and tea seed oil are commonly used as solvents or oil phase matrices in pharmaceutical formulations. However, due to the susceptibility of plant oils to oxidation and rancidity, which affects the long-term stability of pharmaceutical formulations, research has found that after hydrogenation, plant oils are less prone to oxidation and rancidity, and their oil properties do not undergo significant changes.
Therefore, for ointments and suppositories that require vegetable oil or liquid paraffin, hydrogenated castor oil can be used. As hydrogenated castor oil is a waxy solid with a high viscosity after melting, it can significantly reduce the amount of oil or oil phase used, and the paste is smoother and more delicate.
